The antibiotic contaminants from drug abuse, aquaculture wastewater and pharmaceutical industry effluent have enormous threat to microecology and human beings. In this paper, a porous hexagonal boron nitride (p-BN), which has high surface area up to 1062.88 m(2) g(-1) and abundant pore structure, was prepared and characterized by XRD, SEM, FT-IR and physical-chemical isothermal adsorption. A systematical and comprehensive study of the adsorption kinetics, thermodynamics and isotherms of tetracycline (TC) on p-BN has been completed. Meanwhile, the effects of pH, temperature and salinity were also considered. It still had a rapidly adsorption rate and effective removal percentage (94.25%) to TC at high concentration. The maximum adsorption capacity can achieve to 322.16 mg g(-1) at the concentration of 160 mg L-1. Pseudo-second-order model and intra-particle diffusion model correlate with the experiment data better, the molecular diffusion of TC in the p-BN micropores is the rate-limiting step. Adsorption process was spontaneous and exothermic due to the thermodynamic calculation, lower temperatures is favorable to the adsorption process. Salting out effect made the adsorption capacity increases with the added Na+ ion. The adsorption isotherms were more accordant with the Freundlich and Tempkin model. The adsorption mechanisms were mainly pi-pi interaction and electrostatic force. (C) 2017 Elsevier B.V. All rights reserved.