The objective of this study was to analyse the effectiveness of different Advanced Oxidation Processes based on solar and ultraviolet C radiation to remove the antibiotic tinidazole (TNZ) from water. Specifically the systems studied were: UVC, solar radiation, UVC/H2O2, solar/H2O2, UVC/K2S2O8, solar/K2S2O8, UVC/photo-Fenton and solar/photo-Fenton. Some aspects of these processes such as the degradation percentage of TNZ, its mineralisation degree, and the degradation products, were analysed. The direct photodegradation of TNZ showed low yields, with a removal percentage lower than 50%. With the UVC/H2O2 system, the percentage of TNZ degraded increased with the H2O2 concentration, but when solar radiation was used, the addition of H2O2 did not favour the process efficiency. The UVC/K2S2O8 system was more efficient than UVC/H2O2 for TNZ degradation. The presence of K2S2O8 in the solar photodegradation also enhanced TNZ degradation in comparison to the direct photolysis process. In the photo-Fenton systems, for both UVC and solar radiations, high levels of TNZ degradation and mineralisation were obtained. Therefore, the photo-Fenton systems are the most recommended to treat water contaminated with TNZ. Some clues of the mineralisation process appear from the degradation products detected by means of coupled ultra-pressure liquid chromatography and high-resolution mass spectrometry. (C) 2017 Elsevier B.V. All rights reserved.