Recent developments in C-H bond activation and functionalization by Pt complexes are surveyed. Topics include the following: fundamental mechanistic investigations of C-H activation; stoichiometric intra- and intermolecular C-H activation; reactions of dioxygen with Pt(II) complexes that may be relevant to substrate oxygenation; and both stoichiometric and catalytic formation of C-O, C-C, and C-B bonds via C-H activation. Current interests and trends are discussed, both in the context of historical work and to forecast future directions and opportunities for the field.