Herein we report the syntheses, characterization, photophysical and photochemical properties, and in vitro biological efficacy of Zn(II) and In(III) porphyrins coordinated with Pt(II) groups. In-Pt porphyrin showed excellent therapeutic potential in BALB/c mice having Colon26 tumors. These results imply that the mixed-metal complex In-4cisPtTPyP could be a promising anticancer agent for photodynamic therapy.