Currently, Me-N-C catalysts are the most prominent alternative to Pt/C catalysts for the oxygen reduction reaction in acidic media. It is well known that the achievable activity and selectivity strongly correlates with the nature of metal species. However, so far the effect of the metal species on the stability of these catalysts was not investigated systematically. In this work, a group of 13 different Me-N-C catalysts were investigated with respect to their activity and stability in accelerated stress tests mimicking the start-up and shut-down conditions (AST_SSC). A strong correlation between the nitrogen content assigned to different MeN4 sites and the D-3 band from Raman spectroscopy is found. Moreover, we were able to correlate changes in the D-3 band and variations in the displacement of the metal atoms out of the N-4 plane with the losses in ORR activity. Based on these findings, we propose a model for the degradation of Me-N-C catalysts during accelerated stress tests mimicking the start-up and shut-down conditions. (C) 2017 Published by Elsevier Ltd.