This study presents a comparison of the optimisation of building energy retrofit strategies from two different perspectives: an energy/economic-based analysis and an exergy/exergoeconomic-based analysis. A recently retrofitted community centre is used as a case study. ExRET-Opt, a novel building energy/exergy simulation tool with multi-objective optimisation capabilities based on NSGA-II is used to run both analysis. The first analysis, based on the 1st Law only, simultaneously optimises building energy use and design's Net Present Value (NPV). The second analysis, based on the 1st and the 2nd Laws, simultaneously optimises exergy destructions and the exergoeconomic cost-benefit index. Occupant thermal comfort is considered as a common objective function for both approaches. The aim is to assess the difference between the methods and calculate the performance among main indicators, considering the same decision variables and constraints. Outputs show that the inclusion of exergy/exergoeconomics as objective functions into the optimisation procedure has resulted in similar 1st Law and thermal comfort outputs, while providing solutions with less environmental impact under similar capital investments. This outputs demonstrate how the 1st Law is only a necessary calculation while the utilisation of the 1st and 2nd Laws becomes a sufficient condition for the analysis and design of low carbon buildings. (C) 2017 Elsevier Ltd. All rights reserved.