As an important way to increase industrial energy efficiency, Waste Heat to Power (WHP) technologies have been gaining popularity in recent years. In order to appraise the market potential of WHP technologies in Southeast Asia, a techno-economic assessment for WHP technologies is conducted in this paper. The technical and economic market potential of WHP in Southeast Asia is estimated to be 1788 MW and 1188 MW respectively. The main market drivers and barriers for WHP market expansion in Southeast Asia are also analyzed. Given the fact that WHP is a far cheaper power generation technology as compared with traditional and renewable power generation, the WHP market is expected to increase fast in the coming years. Mounting electricity price from grid, government emissions regulations and subsidies, the integration of WHP products with original equipment manufacturer, capital cost reduction induced by technology development are identified as the key drivers for the market growth. The above arguments are proofed through the analysis of a power plant WHP project in Southeast Asia.