화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Applied Chemistry for Engineering, Vol.28, No.4, 397-403, August, 2017
DOI10.14478/ace.2017.1069  Export Citation
알츠하이머 질병 진단을 위한 혈액 바이오마커 검출용 바이오칩 센서 개발
Development of Biochip Sensors for Blood Biomarkers Specific to Alzheimer’s Disease Diagnostics
김수희, 이상혁, 이혜진†
  • 경북대학교 자연과학대학 화학과 및 청정나노소재 연구소
Suhee Kim, Sang Hyuk Lee, and Hye Jin Lee†
  • Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu-city 41566, Republic of Korea
E-mail:
초록
해마다 증가하는 알츠하이머 질병에 걸린 환자 수는 전체 노인 인구의 15%에 다다르고 있다. 인지장애를 유발하는 심각한 알츠하이머 질병을 조기에 진단하는 것은 중요한 일이지만 MRI, PET, 척수액 진단법과 같은 기존 진단법은 고비용뿐만 아니라 장시간의 진단으로 환자에게 부담을 줄 수 있다. 이러한 기존 알츠하이머 질병 진단법의 단점을 극복하기 위하여 소량의 환자 시료(예 : 혈액)만으로 신속하게 알츠하이머 질병을 조기에 진단할 수 있는 다양한 바이오센싱 기술을 개발하는 연구가 지속되고 있다. 본 미니총설에서는 알츠하이머 질병 진단에 유용하게 활용될 수 있는 혈액 바이오마커를 정성 및 정량적으로 검출할 수 있는 바이오칩 기반의 센서 기술과 이를 통한 조기진단 기술에 대해 간략하게 서술하고, 이와 관련한 최신 연구현황과 발전방향에 대해 논의하고자 한다.
The number of patients suffering from Alzheimer’s disease is increasing year after year and almost approaching 15% of the total elderly population. Although it is critical to detect the early stage of Alzheimer’s disease, which is a serious illness causing cognitive deficits, various existing diagnosis methods such as MRI, PET and CSF analysis could be the burdens for patients due to their high costs and long time to diagnosis. In order to tackle some of challenging issues for such existing diagnosis methods, extensive efforts have been made on developing fast and convenient biochip sensing methodologies for the diagnosis of Alzheimer’s disease with a droplet of patient biofluids (e.g., blood). In this mini-review, we highlight some of the latest biochip sensing technologies that could qualitatively and quantitatively analyze blood biomarkers used for lzheimer’s disease diagnostics and discuss briefly related research trends and future aspects.
Keywords:Alzheimer’s disease;blood biomarker;biochip sensors;surface plasmon resonance;surface sandwich assay
  1. Bateman RJ, Xiong C, Benzinger TLS, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor M, N. Engl. J. Med., 367, 795 (2012)
  2. Holger J, Dialogues Clin. Neurosci., 15, 445 (2013)
  3. Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipe, Alzheimers Dement, 12, 292 (2016)
  4. Accorroni A, Giorgi FS, Donzelli R, Lorenzini L, Prontera C, Saba A, Vergallo A, Tognoni G, Siciliano G, Baldacci F, Bonuccelli U, Clerico A, Zucchi R, Endocrine, 55, 981 (2017)
  5. Liu L, Xia N, Wang J, RSC Adv., 2, 2200 (2012)
  6. Park SA, Kim JH, Kim HJ, Kim TE, Kim YJ, Lee DH, Park JH, Chae WS, Yim SJ, Seo SW, Na DL, Choi SH, Dement. Neurocogn. Disord., 12, 1 (2013)
  7. Zhou W, Huang PJJ, Ding J, Liu J, Analyst, 139, 2627 (2014)
  8. Yeo LY, Chang HC, Chan PPY, Friend JR, Small, 7, 12 (2011)
  9. Ye GJ, Oshins RA, Rouhani FN, Brantly ML, Chulay JD, J. Immunol. Methods, 388, 12 (2013)
  10. Li H, Ya C, Wu X, Ye Z, Li G, Talanta, 93, 358 (2012)
  11. Olaru A, Bala C, Renault NJ, Enein HYA, Crit. Rev. Anal. Chem., 45, 97 (2015)
  12. Englund H, Sehlin D, Johansson AS, Nilsson LNG, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE, J. Neurochem., 103, 334 (2007)
  13. Levy S, McConville M, Lazaro GA, Averback P, J. Clin. Lab. Anal., 21, 24 (2007)
  14. Diba FS, Kim S, Lee HJ, Biosens. Bioelectron., 72, 355 (2015)
  15. Homola J, Yee SS, Gauglitz G, Sens. Actuators B-Chem., 54, 3 (1999)
  16. Corn RM, Weibel SC, Fourier transform surface plasmon resonance in Handbook of vibrational spectroscopy, vol. 2, J. M. Chalmers and P. R. Griffiths (eds), John Wiley & Sons, Ltd, 1057-1064 (2006).
  17. Brockman JM, Nelson BP, Corn RM, Annu. Rev. Phys. Chem., 51, 41 (2000)
  18. Mayer KM, Hafner JH, Chem. Rev., 111(6), 3828 (2011)
  19. Cho CM, Kim SH, Yoon SM, Ko YH, Jun JP, Soung JH, Public Health Wkly. Rep., 8, 618 (2015)
  20. Olsson B, Lautner R, Andreasson U, Ohrfelt A, Portelius E, Bjerke M, Holtta M, Rosen C, Olsson C, Strobel G, Wu E, Dakin K, Petzold M, Blennow K, Zetterberg H, Lancet Neurol., 15, 673 (2016)
  21. Thambisetty M, Lovestone S, Biomark. Med., 4, 65 (2010)
  22. Blennow K, Hampel H, Lancet Neurol., 2, 605 (2003)
  23. Humpel C, Trends Biotechnol., 29, 26 (2011)
  24. Baird AL, Westwood S, Lovestone S, Front Neurol., 6, 1 (2015)
  25. Ramakrishnan M, Kandimalla KK, Wengenack TM, Howell KG, Poduslo JF, Biochemistry, 48, 10405 (2009)
  26. Diba FS, Kim S, Lee HJ, Electrochemical immunoassay for amyloid-beta 1-42 peptide inbiological fluids interfacing with a gold nanoparticle modified carbonsurface, Catal. Today, https://doi.org/10.1016/j.cattod.2017.02.039.
  27. Kim S, Lee HJ, Anal. Chem., 87, 7235 (2015)
  28. Kim S, Wark AW, Lee HJ, Anal. Chem., 88, 7793 (2016)
  29. Hegnerova K, Bockova M, Vaisocherova H, Kristofikova Z, Ricny J, Ripova D, Homola J, Sens. Actuators B-Chem., 139, 69 (2009)
  30. Velayudhan L, Killick R, Hye A, Kinsey A, Guntert A, Lynham S, Ward M, Leung R, Lourdusamy A, To AWM, Powell J, Lovestone S, J. Alzheimers Dis., 28, 369 (2012)
  31. Thambisetty M, An Y, Kinsey A, Koka D, Saleem M, Guntert A, Kraut M, Ferrucci L, Davatzikos C, Lovestone S, Resnick SM, Neurolmage, 59, 212 (2012)
  32. Tonello S, Serpelloni M, Lopomo NF, Abate G, Uberti DL, Sardini E, Procedia Eng., 168, 147 (2016)
  33. Jang HR, Wark AW, Baek SH, Chung BH, Lee HJ, Anal. Chem., 86, 814 (2014)
  34. Kwon MJ, Lee J, Wark AW, Lee HJ, Anal. Chem., 84, 1702 (2012)
  35. Zeng S, Baillargeat D, Ho HP, Yong KT, Chem. Soc. Rev., 43, 3426 (2014)
  36. Henriksen K, Wang Y, Sorensen MG, Barascuk N, Suhy J, Pedersen JT, Duffin KL, Dean RA, Pajak M, Christiansen C, Zheng Q, Karsdal MA, PLoS ONE, 8, 1 (2013)
  37. Grijalba VP, Pesini P, Monleon I, Boada M, Tarraga L, Laza AR, Lage PM, Jose IS, Sarasa M, J. Alzheimers Dis., 36, 211 (2013)
  38. Liu Y, Zhou Q, Revzin A, Analyst, 138, 4321 (2013)
  39. Vestergaard M, Kerman K, Saito M, Nagatani N, Takamura Y, Tamiya E, J. Am. Chem. Soc., 127(34), 11892 (2005)
  40. Abdulhalim I, Zourob M, Lakhtakia A, Electromagnetics, 28, 214 (2008)
  41. Endo T, Kerman K, Nagatani N, Takamura Y, Tamiya E, Anal. Chem., 77, 6976 (2005)
  42. Hoa XD, Kirk AG, Tabrizian M, Biosens. Bioelectron., 23, 151 (2007)
  43. Jung SH, Jung JW, Suh IB, Yuk JS, Kim WJ, Choi EY, Kim YM, Ha KS, Anal. Chem., 9, 5703 (2007)
  44. Li Y, Lee HJ, Corn RM, Anal. Chem., 79, 1082 (2007)
  45. Bini A, Centi S, Tombelli S, Minunni M, Mascini M, Anal. Bioanal. Chem., 90, 1077 (2008)
  46. Ladd J, Taylor AD, Piliarik M, Homola J, Jiang S, Anal. Bioanal. Chem., 393, 1157 (2009)
  47. Vaisocherova H, Faca VM, Taylor AD, Hanash S, Jiang S, Biosens. Bioelectron., 24, 2143 (2009)
  48. Altintas Z, Uludag Y, Gurbuz Y, Tothill IE, Talanta, 86, 377 (2011)
  49. Zhao Q, Duan R, Yuan J, Quan Y, Yang H, Xi M, Int. J. Nanomed., 9, 1097 (2014)
  50. Masson JF, ACS Sens., 2, 16 (2017)
  51. Homola J, Chem. Rev., 108(2), 462 (2008)
  52. Haes AJ, Hall WP, Chang L, Klein WL, Duyne RPV, Nano Lett., 4, 1029 (2004)
  53. Haes AJ, Chang L, Klein WL, Van Duyne RP, J. Am. Chem. Soc., 127(7), 2264 (2005)
  54. Shekhar S, Kumar R, Rai N, Kumar V, Singh K, Upadhyay AD, Tripathi M, Dwivedi S, Dey AB, Dey S, PLoS ONE, 11, 1 (2016)
  55. Lee HJ, Wark AW, Corn RM, Analyst, 133, 975 (2008)
  56. Sonawane MD, Nimse SB, J. Chem., 2016, 1 (2016)