The interaction of Mn(ClO4)(2)center dot 6H(2)O with salicylaldoxime (H(2)sao) in the presence of nonsteroidal anti-inflammatory drug (NSAID) sodium didofenac (Nadid) or indomethacin (Hindo) leads to the formation of the hexanuclear Mn(III) clusters [Mn-6(O)(2)(did)(2)(sao)(6)(CH3OH)(6)] (1) and [Mn-6(O)(2)(indo)(2)(sao)6(H2O)(4)] (2) both characterized as stepladder inverse-9-metallacrown-3 accommodating did- or indo- ligands, respectively. When the interaction of MnCl2 center dot 4H(2)O with Nadicl or Hindo is in the absence of H(2)sao, the mononuclear Mn(II) complexes [Mn(did)(2)(CH3OH)(4)] (3) and [Mn(indo)(2)(CH3OH)(4)] (4) were isolated. The complexes were characterized by physicochemical and spectroscopic techniques, and the structure of complexes 1 and 2 was characterized by X-ray crystallography. Magnetic measurements (dc and ac) were carried out in order to investigate the nature of magnetic interactions between the magnetic ions and the overall magnetic behavior of the complexes.