Enantioseparation is an integral process hi the phatthaceutical industry, considering the ever-increasing demand for chiral medicthe products. As a new material, porous metal-organic frameworks (MOFs) have shown their potential application in this field=becaue their structures are easy to adjust and control. Though chiral recognition between racemic substrates and frameworks has made preliminary progress, discusSions of their size-matching effects are rare. Herein with the help of channel-tunable homochiral MOFs (HMOFs), dials of different sizes have been separated in good enantiomeric excess (ee%). In addition,,the ee% reaches 67.4% for the first tithe for dials as large as 1,1,2-tripheny1-1,2-ethanediol, which turns out to be the most effective value so far.