In the present study, a comprehensive generic model is developed for pressure swing adsorption process. The model overcomes the inadequacy related to frozen solid concept, isothermality assumption etc. and treats them as per physics of adsorption as well as hydrodynamics. Results are presented to show that there is significant adsorption/desorption during pressure changing steps (pressurization, blowdown), which in turn has significant effect on process performance. Hydrogen pressure swing adsorption process demands high purity and recovery, which can be achieved by complex cycle configuration. It has been used as a case study. The model is validated using the reported simulation/experimental data to the extent possible. The present study reports separation of Hydrogen from five-component mixture using a six-bed process. The dynamics of the process were studied and are presented incorporating non-isothermal effects. The model is easily adaptable to different adsorption/desorption kinetics and thermodynamics due to its effective decoupling of bed hydrodynamics from adsorption/desorption. (C) 2016 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.