Pressurized CO2 and LPG were used to extract chia oil at different pressures and temperatures. The effects of the latter on oil yield, antioxidant activity, and the profiles of fatty acids and phytosterols were evaluated. The optimal yields were obtained under the conditions of higher pressure and temperature for both CO2 (21.93%) and LPG (27.13%). Under the same conditions, the oil extracted with LPG had higher antioxidant activity in DPPH than that extracted with CO2 (70.16 AA% and 20.15 AA%, respectively). The fatty acid profile was similar between the two solvents, and a-linolenic acid predominated. Bioactive compounds such as squalene, atocopherol and beta-sitosterol were quantified.