The iodine pentoxide is one of the most advanced oxidizers for nanostructured energetic formulations among the thermites due to the highest energy release per volume 25.7 kJ cm(-3). The size and shape of iodine pentoxide particles have a strong impact on the pressurization rates during the reaction. Although micro-sized iodine pentoxide particles are commercially available, nano-sized particles, which are desired for various nano-energetic applications, are not available on the market. Conventional wet chemical methods are unable to produce iodine pentoxide nanoparticles due to high solubility in water. In this study, we demonstrate fabrication of iodine pentoxide nano-rods by high energy mechanical treatment of micro-sized I2O5 particles. Tuning the energy dose in high-energy ball milling is allowing to produce I2O5 nano-rods with diameter of 50-100 nm and length of 300-600 nm. The produced nano-rods exhibited 10% smaller decomposition energy compared to the precursor of micro particles. The experiments showed that the nano-energetic materials prepared with nano-sized I2O5 rods have pressure discharge value of 43.4 MPag(-1) which is two times higher than using commercial iodine pentoxide particles.