Low product concentration and high cost of recovery process have motivated the study of in situ removal of fumaric acid from fermentation broth. After a series of screenings, an integrated process with fumaric acid fermentation and extraction was developed. Under this integrated process, fumaric acid production and productivity increased from 18.06 g/L to 34.23 g/L, and from 0.27 g/L/h to 0.57 g/L/h, respectively. Neutralizing agent utilization decreased by 58.75%, and 140.7 g/L ammonium fumarate was obtained after back extraction, which could be directed used to produce related derivatives without concentration. Thus, the integrated process was more economic and environmental friendly.