One-pot 합성을 통해 천연 화합물이 삽입된 아미노클레이 제조 및 항균성 연구

김성열; 최유성; Seong Yeol Kim; Yoo-Sung Choi

Applied Chemistry for Engineering, Vol.28, No.5, 495-500, October, 2017

DOI10.14478/ace.2017.1034 Export Citation

One-pot 합성을 통해 천연 화합물이 삽입된 아미노클레이 제조 및 항균성 연구

Preparation of Natural Chemicals Intercalated Aminoclay via One-pot Synthesis and its Antimicrobial Property

김성열, 최유성^{1, †}

(주)럭키산업 연구개발팀
¹조선이공대학교 생명환경화공과

Seong Yeol Kim, and Yoo-Sung Choi^{1, †}

R&D Team, Lucky Industry, Gwangsan-gu, Gwangju 62230, Korea
¹Department of Bioenvironmental & Chemical Engineering, Chosun College of Science & Technology, Dong-gu, Gwangju 61453, Korea

E-mail:

초록

본 연구에서는 마그네슘 이온 및 (3-aminopropyl)triethoxysilane (APTES)으로 표면에 amine group이 부착된 아미노클레이를 합성(AC)함과 동시에 천연 화합물인 프로폴리스 및 황련 추출물을 클레이 시트 사이에 삽입한 클레이를 합성(PIAC, CIAC)하였다. 주사전자현미경, 입도 분석법, FT-IR, TGA 및 XRD를 통해 클레이의 합성 및 천연 화합물의 삽입을 확인하였고, 특히 XRD data에서 천연 화합물의 삽입에 따른 층간거리(d-space)를 분석함으로써 명확하게 그 특성을 결정하였다. 또한 천연 화합물이 삽입된 클레이인 PIAC 및 CIAC의 경우 삽입되지 않은 아미노클레이(AC)에 비해 항균성이 향상된 것을 최소저해농도(MIC) 분석을 통해 확인하였다.

In this study, we synthesized the aminoclay (AC) with magnesium ions and 3 aminopropyl triethoxysilane (APTES). At the same time, propolis intercalated aminoclay (PIAC) and coptis extract intercalated aminoclay (CIAC) were synthesized by intercalating natural chemicals between clay sheets. Clay synthesis and natural chemical intercalation were confirmed through SEM, particle size analyze, FT-IR, TGA and XRD. In particular, the characterization of intercalation of natural chemicals was determined by analyzing the interlayer distance from XRD data. The antimicrobial property of PIAC and CIAC was checked by minimum inhibitory concentration (MIC) test and increased compared with that of the pristine aminoclay (AC).

Keywords:natural chemicals;aminoclay;one-pot synthesis;clay intercalation;antimicrobial

[References]

Lee Y, Choi Y, Choi M, Yang H, Liu K, Shin H, Appl. Clay Sci., 83-84, 474 (2013)
Kim SY, Hwang JY, Seo JW, Shin US, J. Colloid Interface Sci., 442, 147 (2015)
Upadhyay AN, Tiwari RS, Singh K, Mater. Lett., 164, 449 (2016)
Eltohamy M, Seo J, Hwang J, Jang W, Kim H, Shin US, Colloids Surf. B: Biointerfaces, 144, 229 (2016)
Kim S, Kim SY, Shin US, Compos. Sci. Technol., 126, 78 (2016)
Wang G, Yang M, Li Z, Lin K, Jin W, Xing C, Hu Z, Wang D, J. Nanopart. Res., 15, 1882 (2013)
Fujioka K, Iwamoto T, Shima H, Tomaru K, Saito H, Ohtsuka M, Yoshidome A, Kawamura Y, Manome Y, Molecules, 21, 474 (2016)
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ, Adv. Drug Deliv. Rev., 46, 3 (2001)
Krall N, Pretto F, Decurtins W, Bernardes GJL, Supuran CT, Neri D, Angew. Chem.-Int. Edit., 53, 4231 (2014)
Tu Y, Chen Q, Wang S, Uri A, Yang X, Chu J, Chen J, Luo B, Chen X, Wen S, Pi R, RSC Adv., 6, 58516 (2016)
Kim SY, Hwang JY, Shin US, J. Colloid Interface Sci., 465, 18 (2016)
Goh CH, Heng PWS, Chan LW, Carbohydr. Polym., 88, 1 (2012)
Kim T, Kim H, Choi A, Choi H, Bae Y, Oh J, Food Eng. Prog., 19, 360 (2015)
Newman DJ, Cragg GM, J. Nat. Prod., 75, 311 (2012)
Jhang K, Wang Y, Hillmyer MA, Francis LF, Biomaterials, 25, 2489 (2004)
Bankova V, J. Ethnopharmacol., 100, 114 (2005)
Elbakry KA, Omar NA, Nasr SM, J. Pigment. Disord., Doi:10.4172/2376-0427.1000197.
Babaei S, Rahimi S, Torshizi MAK, Tahmasebi G, Miran SNK, Vet. Res. Forum, 7, 13 (2016)
Kim S, Chung H, Korean J. Food Sci. Technol., 45, 370 (2013)
Bae J, Korean J. Food Nutr., 18, 81 (2005)
Park S, Lim YK, Kook J, Int. J. Oral Biol., 40, 79 (2015)
Ko JS, Ahn ET, Park KH, Kim JG, Korean J. Phys. Anthropol., 15, 185 (2002)
Hyun S, Jung S, Jwa M, Song C, Kim J, Lim S, Korean J. Food Sci. Technol., 39, 200 (2007)
Rhee JS, Park HK, Woo ER, Lee EJ, Ahn DK, Youn WS, Shin KH, Coptidis rhizoma, Anal. Sci. Technol., 10, 83 (1997)
Han H, Lee Y, Lee M, Patil AJ, Shin H, ACS Appl. Mater. Interfaces, 3, 2564 (2011)
Haraguchi K, Polym. J., 43, 223 (2011)
He H, Ma Y, Zhu J, Yuan P, Qing Y, Appl. Clay Sci., 48, 67 (2010)
Kim HK, Joo KJ, J. Korean Soc. Food Sci. Nutr., 34, 750 (2005)
Lee Y, Jin E, Jung SW, Kim Y, Chang KS, Yang J, Kim S, Kim Y, Shin H, Sci. Rep., Doi:10.1038/srep01292.

[Referenced By]

[1] Lee Y, Choi Y, Choi M, Yang H, Liu K, Shin H, Appl. Clay Sci., 83-84, 474 (2013)

[2] Kim SY, Hwang JY, Seo JW, Shin US, J. Colloid Interface Sci., 442, 147 (2015)

[3] Upadhyay AN, Tiwari RS, Singh K, Mater. Lett., 164, 449 (2016)

[4] Eltohamy M, Seo J, Hwang J, Jang W, Kim H, Shin US, Colloids Surf. B: Biointerfaces, 144, 229 (2016)

[5] Kim S, Kim SY, Shin US, Compos. Sci. Technol., 126, 78 (2016)

[6] Wang G, Yang M, Li Z, Lin K, Jin W, Xing C, Hu Z, Wang D, J. Nanopart. Res., 15, 1882 (2013)

[7] Fujioka K, Iwamoto T, Shima H, Tomaru K, Saito H, Ohtsuka M, Yoshidome A, Kawamura Y, Manome Y, Molecules, 21, 474 (2016)

[8] Lipinski CA, Lombardo F, Dominy BW, Feeney PJ, Adv. Drug Deliv. Rev., 46, 3 (2001)

[9] Krall N, Pretto F, Decurtins W, Bernardes GJL, Supuran CT, Neri D, Angew. Chem.-Int. Edit., 53, 4231 (2014)

[10] Tu Y, Chen Q, Wang S, Uri A, Yang X, Chu J, Chen J, Luo B, Chen X, Wen S, Pi R, RSC Adv., 6, 58516 (2016)

[11] Kim SY, Hwang JY, Shin US, J. Colloid Interface Sci., 465, 18 (2016)

[12] Goh CH, Heng PWS, Chan LW, Carbohydr. Polym., 88, 1 (2012)

[13] Kim T, Kim H, Choi A, Choi H, Bae Y, Oh J, Food Eng. Prog., 19, 360 (2015)

[14] Newman DJ, Cragg GM, J. Nat. Prod., 75, 311 (2012)

[15] Jhang K, Wang Y, Hillmyer MA, Francis LF, Biomaterials, 25, 2489 (2004)

[16] Bankova V, J. Ethnopharmacol., 100, 114 (2005)

[17] Elbakry KA, Omar NA, Nasr SM, J. Pigment. Disord., Doi:10.4172/2376-0427.1000197.

[18] Babaei S, Rahimi S, Torshizi MAK, Tahmasebi G, Miran SNK, Vet. Res. Forum, 7, 13 (2016)

[19] Kim S, Chung H, Korean J. Food Sci. Technol., 45, 370 (2013)

[20] Bae J, Korean J. Food Nutr., 18, 81 (2005)

[21] Park S, Lim YK, Kook J, Int. J. Oral Biol., 40, 79 (2015)

[22] Ko JS, Ahn ET, Park KH, Kim JG, Korean J. Phys. Anthropol., 15, 185 (2002)

[23] Hyun S, Jung S, Jwa M, Song C, Kim J, Lim S, Korean J. Food Sci. Technol., 39, 200 (2007)

[24] Rhee JS, Park HK, Woo ER, Lee EJ, Ahn DK, Youn WS, Shin KH, Coptidis rhizoma, Anal. Sci. Technol., 10, 83 (1997)

[25] Han H, Lee Y, Lee M, Patil AJ, Shin H, ACS Appl. Mater. Interfaces, 3, 2564 (2011)

[26] Haraguchi K, Polym. J., 43, 223 (2011)

[27] He H, Ma Y, Zhu J, Yuan P, Qing Y, Appl. Clay Sci., 48, 67 (2010)

[28] Kim HK, Joo KJ, J. Korean Soc. Food Sci. Nutr., 34, 750 (2005)

[29] Lee Y, Jin E, Jung SW, Kim Y, Chang KS, Yang J, Kim S, Kim Y, Shin H, Sci. Rep., Doi:10.1038/srep01292.