Although ternary chalcogenide compounds are effective photocatalysts for degrading organic pollutants under visible-light irradiation, their photocatalytic activity and stability are still low and far from practical application. In this study, two-dimensional AgInS2/SnIn4S8 nanosheet heterojunctions were fabricated by one-step hydrothermal method. AgIn52/SnIn4S8 nanosheet heterojunctions have strong visible-light absorption and narrow band gap of 2.27-2.35 eV, and exhibit excellent visible-light photocatalytic activity in the degradation of 2-nitrophenol (2NP) and tetracycline hydrochloride (TC.HCl) compared with pure AgInS2 and pure SnIn4S8, which is attributed to the efficient separation of photogenerated electrons and holes. The practical application of AgInS2/SnIn4S8 nanosheet heterojunctions was further studied. 20 mg AgInS2/SnIn4S8 heterojunctions can effectively treat 100 mL real pharmaceutical industry wastewater in presence of H2O2 with 65.98% mineralization efficiency, and the chemical oxygen demand (COD) of pharmaceutical industry wastewater decreases to 153 mg/L, which meets the discharge standards of industrial effluent. Moreover, AgInS2/SnIn4S8 heterojunctions can maintain long-term activity without obvious inactivation after five consecutive catalytic cycles without using regeneration means. (C) 2017 Published by Elsevier B.V.