Calibration and sensitivity studies in the computational fluid dynamics (CFD) simulation of process equipment such as the annular jet pump are suitable for design, analysis, and optimization. The application of CFD for such purposes is computationally intensive. Hence, an alternative approach with kriging-based meta-models was utilized. Calibration via the adjustment of two turbulent model parameters, C-mu and C-2 epsilon, and likewise two parameters in the simulation correlation for C-mu was considered, while sensitivity studies were based on C-mu as input. The meta-model-based calibration aids exploration of different parameter combinations. Computational time was also reduced with kriging-assisted sensitivity studies which investigated the effect of different C-mu values on pressure distribution.