This paper presents a phase-field simulation of phase separation for a polymer/solvent system and aims at investigating in a systematic way the influence of the mobility model on the simulation results. In 2D geometry, the Flory-Huggins theory was used to describe the thermodynamics of the PMMA/cyclohexanol system and four mobility models were tested: a constant model, a slow model, a fast model and a mobility model based on the free-volume theory of Vrentas. The simulated patterns were analyzed by Fourier transform and using Minkowski descriptors. Growth laws deduced from a Fourier Transform of the patterns exhibited that the power laws were ranged between 1/5 and 1/3 depending on the quenching conditions (T and initial composition) and the mobility model. Using the Vrentas mobility model, growth laws of L-c similar to t(1/5), L-c similar to t(1/4) and L-c similar to t(1/3) were found for initial compositions in the range phi(init) = 0.075, 0.140 and 0.200, respectively, whereas due to faster phase inversion dynamics, a growth law close to L-c similar to t(1/3) was simulated for the constant mobility model whatever the quenching conditions (T and initial composition), thus demonstrating the importance to choose an appropriate mobility model for simulating the phase separation of polymer/solvent system. (C) 2017 Elsevier Ltd. All rights reserved.