The solid acid SO42-/TiO2 was prepared by immersion method and applied for synthesis of propylene glycol methyl ether acetate (PMA) through esterification reaction of propylene glycol monomethyl ether (PM) and acetic acid (HAc). The optimal catalyst preparation condition was determined by orthogonal analysis of parameters in a five-factor and four-level test. The obtained solid acid catalysts were characterized in detail by means of X-ray powder diffraction, thermogravimetry, pyridine adsorbed IR analysis, scanning electron microscopy, and BET surface area method. Synthesis of PMA was studied in this paper through experimental investigation of reaction conditions such as temperature, molar ratio of reactants, catalyst dosage and agitation speed. Based on its possible reaction mechanism, a pseudo-homogeneous kinetic model was established and its activation energies E-a(+) and E-a(-), 65.68 x 10(3) J.mol(-1) and 57.78 x 10(3) J.mol(-1), were estimated. To prepare shaped solid acid catalyst SO42-/TiO2, the shaping method of impregnation-shaping-impregnation was applied. The optimal molding formulation of solid acid catalyst, obtained from the orthogonal test, was found to be binder 7 wt%, reinforcing agent 20 wt%, pore forming material 2.5 wt%, and lubricant 4 wt%. The results of performance test of catalyst demonstrated that the shaped solid acid catalyst exhibited high activity and stability. (C) 2016 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.