The degradation of polypyrrole (PPy) coated iron is studied in phosphate buffer saline solution at 37 degrees C by odd random phase multisine electrochemical impedance spectroscopy (ORP-EIS). PPy is electro-polymerized with anti-inflammatory salicylates incorporated in the film, as a drug release system. The modelling of EIS over time provides the quantitative description of the corrosion behaviour of the material. Thus, the reliable analysis of the degradation stages of PPy coated iron is attained. The outcome of the present study shows that the degradation of iron can be tailored by tuning the properties of the PPy coating for possible medical applications. (C) 2017 Elsevier Ltd. All rights reserved.