MgO/ceramic honeycomb (MgO/CH) composite material was prepared by the excessive impregnation method, and its catalytic activity in ozonation of acetic acid at initial neutral pH value was investigated. It was found that the efficiency of ozonation in the presence of MgO/CH (81.6% acetic acid removal in 30 min) was greatly enhanced compared to that (only 18.7%) in the absence of MgO/CH under the same conditions. Besides the increase in pH value of the solution caused by MgO/CH, the surface active sites of MgO/CH also accelerated ozone decomposition, thus bringing about the further high efficiency of ozonation. Therefore, MgO/ceramic honeycomb is a potential catalyst in ozonation process.