Multiperiod hydrogen network optimization problems may arise from the fluctuations of operating parameters in practical refineries. However, multiperiod operating conditions are always assumed to be known and their effects on the optimization of multiperiod hydrogen network optimization are neglected in current research. To address these problems, a subperiod partitioning method based on dustering of uncertain operating parameters is proposed. A reasonable division of the subperiod and corresponding values of parameters in each subperiod can then be determined by taking a trade-off between the number of subperiods and the quality of subperiod partitioning. The procedure of the proposed method is illustrated via a hydrogen system in a practical refinery. Finally, the effects of subperiod partitioning on the total annual cost and the flexibility of the multiperiod hydrogen network are analyzed and discussed to further verify the application of the proposed method.