To achieve the better electrocatalytic activity and stability of Pd-base catalysts for ethylene glycol and glycerol oxidation reactions, a novel Pd-base binary Pd Co oxides nanoparticles (Pd PdO-CoOx) was synthesized by in-situ oxidation of Pd Co precursor. The strategy was simple, mild, green and efficient. The prepared nanoparticles exhibited a mutually connected, fused irregular nanoparticles in TEM. The as-synthesized Pd PdO-CoOx (1:4) nanoparticles displayed prominent catalytic activity (5.82 A mg,1 for ethylene glycol and 5.16 A mg forfor glycerol) for ethylene glycol and glycerol oxidation reactions in alkaline solution compared to the commercial Pt/C (1.64 A mgp(-1) for ethylene glycol and 1.48 A mg,T, for glycerol) catalyst. The improved electrocatalytic activity of Pd PdO-CoOx catalyst mainly ascribes to the producing Strong Metal-Support Interactions (SMSI) between PdO-CoOx and Pd nanoparticles, the synergistic effect between PdO and CoOx and the presence of CoO promoved hydroxyl adsorption at lower potentials. Combined with the simple synthetic method, lower cost and good performance, Pd PdO-CoOx is a promising catalyst for direct fuel cells. (C) 2017 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.