Mesostructured NiO-CeO2 mixed oxides, with Ni loadings in the range 5-35 wt% (g(Ni)/g(ceo2)); were synthesized by the hard template procedure using SBA-15 as the template. A hard-templated CeO2 was also prepared and used as the support for depositing Ni (5-35 wt%) by impregnation. Two NiO-Al2O3 catalysts were synthesized for comparison, by impregnating nickel on a commercial gamma -alumina. All the samples were characterized by different techniques as to their chemical composition, structure, morphology, texture, and redox features. The catalytic performance was investigated in the CO2 methanation reaction after mild reduction pretreatment (H-2 at 400 degrees C for 1 h). Catalytic testing was performed under atmospheric pressure, 300 degrees C, 72,000 cm(3)h(-1) g(cat)(-1) and stoichiometric H-2/CO2 molar ratio. High catalytic activity, with CH4 selectivity values >= 93 mol%, was obtained with the NiO-CeO2 mixed oxides (CO2 conversions up to 76 mol%). When gamma-Al2O3 was used as the support, catalysts with low activity (CO2 conversion <= 20 mol%) were obtained. On selected samples, additional catalytic runs were also performed for reaction times up to 30 h or with a higher space velocity value. The catalytic results were explained by taking into account the role of the nickel-ceria interactions both during the reduction of NiO and in the reactants activation. (C) 2017 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.