The one-to-one clusters of the 2,5-lutidyl radical [2-CH3,5-(CH2)C5H3N] with Ar, N-2, CH4, CF4, C2H6, C3H8, C4H10, and C2H4 are studied by fluorescence excitation spectroscopy, mass resolved excitation spectroscopy, and ab initio and semiempirical calculational techniques. Cluster binding energies for the ground (D-0) and excited (D-1) states, cluster spectroscopic shifts, and van der Waals cluster vibrational modes are reported for these systems. The agreement between the observed and calculated cluster properties is quite good. Unlike the benzyl radical, the 2,5-lutidyl radical does not react with ethylene in its D-1 excited electronic state.