This study investigated the degradation of 2-nitrophenol (2-NP) in aqueous solution by dielectric barrier discharge (DBD) system alone and its combination with supported TiO2 photocatalysts. The TiO2 photocatalyst supported on a stainless steel mesh was synthesised using sol-gel solution of 8% polyacrylonitrile (PAN)/dimethylformamide/TiCl4 followed by pyrolysis in the furnace under N-2 atmosphere at temperatures of 300, 350, or 400 degrees C for 3 h holding time. The supported catalysts were characterized for their morphologies, functional groups, crystallinity, surface areas and elemental chemical states by high resolution scanning electron microscope (HRSEM), Fourier transform infrared, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface area, and X-ray photoelectron spectroscopy. The influence of solution pH on the degradation of 2-NP was investigated. The residual concentration of 2-NP and the intermediate compounds were quantified and identified using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The concentration of the dissolved ozone, hydrogen peroxide and hydroxyl radicals generated by the DBD in the presence or absence of a catalyst was monitored using ultraviolet-visible spectroscopy and photoluminescence spectroscopy. The HRSEM, HRTEM, XRD and BET analysis revealed that the optimal thermal conditions to obtain well supported uniformly grown, highly active crystalline TiO2 catalysts with high specific surface area was 350 degrees C at a 3 h holding time in N-2 atmosphere with a flow rate of 20 mL/min. The supporting procedure simultaneously carbon doped the photocatalyst. The DBD system alone without catalysts successfully mineralised 58.6% of 2-NP within 60 min while combined DBD/supported TiO2 nanocrystals achieved 77.5% mineralisation within the same treatment time. The increase in mineralisation rate was attributed to the existence of a synergistic effect between the DBD system and the supported catalysts. 2-NP degradation proceeded via hydroxylation, nitration and denitration using DBD alone and combined DBD/Supported TiO2 photocatalyst. Catechol, hydroquinone, hydroxyl-1,4-benzoquinone, 2-nitrohydroquinone, and 2,4-dinitrophenol were identified as major intermediate products. The order of production of free reactive species by DBD alone and combined DBD with supported photocatalyst was OHA degrees A > H2O2 > O-3. The results showed that the combined system was more than effective than DBD alone for the degradation of the 2-NP in aqueous solution.