Hierarchical ZSM-5 zeolite has been successfully synthesized using carboxymethyl cellulose (CMC) as a mesotemplate. The synthesized samples were characterized by using XRD, FT-IR, Al-NMR spectroscopy, SEM, TEM, TG, N-2 adsorption -desorption and NH3-TPD. They exhibited characteristic MFI structure, which was confirmed by XRD and FT-IR analysis. (27)A1 MAS NMR spectra indicated the presence of tetrahedral coordinated Al in the hierarchical zeolite. SEM and TEM images of the sample showed significant mesoporosity. The N-2 adsorption/desorption results supported the presence of mesopores. Catalytic activity of the prepared mesoporous ZSM-5 for the acetalization of cyclohexanone with methanol was examined. The effects of molar ratio, catalyst amount and time on cyclohexanone conversion were studied. It has been found that the catalytic activity of mesoporous ZSM-5 catalyst is superior to that of the conventional zeolite for the acetalization of cyclo. hexanone with methanol. (C) 2017 Elsevier B.V. All rights reserved.