The stretch-induced wrinkling behaviors in graphene membranes with frozen zone are investigated in molecular dynamics simulations and suppressed by adopting optimal designs obtained in topology optimization. The graphene membranes with optimal designs under stretching are wrinkle-free, this is meaningful to ensure the exceptional performances of graphene-nanoelectronics. Both the wrinkling and wrinkling-suppression mechanisms are qualitatively and quantitatively elucidated with finite element analyses, which are helpful to understand the stretch-induced wrinkling in graphene membranes with frozen zone and to provide useful guidance to the design of the large-area graphene-nanoelectronics. (C) 2017 Elsevier B.V. All rights reserved.