Effective separation of succinic acid by combined crystallization

Eun Hye Kim; Seong-Sik You; Jeong Won Kang

Korean Journal of Chemical Engineering, Vol.35, No.1, 204-209, January, 2018

DOI10.1007/s11814-017-0232-9 Export Citation

Effective separation of succinic acid by combined crystallization

Eun Hye Kim, Seong-Sik You¹, and Jeong Won Kang^†

Department of Chemical and Biological Engineering, Korea University, 5-1, Anam-dong, Sungbuk-gu, Seoul 02841, Korea
¹School of Energy, Material & Chemical Engineering, Korea University of Technology and Education, 1600 Chungjeol-ro, Byeongcheno-myun, Dongnam-gu, Cheonan 31253, Korea

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Succinic acid, which is widely used as a building block chemical, can be produced from either petroleum or renewable resources. Bio-based production of succinic acid requires several purification steps, and the yield of any particular separation method is an important factor in facilitating an economic design. Crystallization is a common method for the purification of succinic acid, and several driving forces can be used to generate solubility changes in the solution. In this work, three driving forces of crystallization - cooling, acidification, and salting out - were examined individually and combined to achieve maximum yield from a solution of succinic acid. It was found that combined crystallization can significantly improve the yield (97.08%) compared with conventional cooling crystallization (84.31%) or acidification (66-67%). Additionally, a basic kinetic study was performed, and a total of 7minutes of batch operation was sufficient to produce the maximum amount of crystals.

Keywords:Cooling Crystallization;Acidification;Salting-out Crystallization;Succinic Acid

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Efe C, Pieterse M, van der Wielen LAM, Straathof AJJ, Chem. Eng. Process., 50(11-12), 1143 (2011)

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[1] Sauer M, Porro D, Mattanovich D, Branduardi P, Trends Biotechnol., 26, 100 (2008)

[2] Cheng KK, Zhao XB, Zeng J, Zhang JA, Bioprod. Bioref., 6, 302 (2012)

[3] Willke T, Vorlop KD, Appl. Microbiol. Biotechnol., 66(2), 131 (2004)

[4] Sun YQ, Yan L, Fu HX, Xiu ZL, Process Biochem., 49(3), 506 (2014)

[5] Bechthold I, Bretz K, Kabasci S, Kopitzky R, Springer A, Chem. Eng. Technol., 31(5), 647 (2008)

[6] Kertes A, King CJ, Biotechnol. Bioeng., 28, 269 (1986)

[7] Huh YS, Jun YS, Hong YK, Song H, Lee SY, Hong WH, Process Biochem., 41(6), 1461 (2006)

[8] Jun YS, Lee EZ, Huh YS, Hong YK, Hong WH, Lee SY, Biochem. Eng. J., 36, 8 (2007)

[9] Song H, Huh YS, Lee SY, Hong WH, Hong YK, J. Biotechnol., 132, 445 (2007)

[10] Hong YK, Hong WH, Sep. Purif. Technol., 42(2), 151 (2005)

[11] Hong YK, Han DH, Hong WH, Korean J. Chem. Eng., 19(1), 83 (2002)

[12] Hong YK, Hong WH, Korean J. Chem. Eng., 21, 488 (2002)

[13] Pratiwi AI, Yokouchi T, Matsumoto M, Kondo K, Sep. Purif. Technol., 155, 127 (2015)

[14] Luque R, Lin CSK, Du C, Macquarrie DJ, Koutinas A, Wang R, Webb C, Clark JH, Green Chem., 11, 193 (2009)

[15] Li Q, Wang D, Wu Y, Li WL, Zhang YJ, Xing JM, Su ZG, Sep. Purif. Technol., 72(3), 294 (2010)

[16] Schlosser S, Kertesz R, Martak J, Sep. Purif. Technol., 41(3), 237 (2005)

[17] Berglund KA, Elankovan P, Glassner DA, U.S. Patent No. 5034105 A (1991).

[18] Efe C, Pieterse M, van der Wielen LAM, Straathof AJJ, Chem. Eng. Process., 50(11-12), 1143 (2011)