As the biofuel industry is heavily depend on technological advancement to remain competent, creation of new process techniques becomes inevitable to replace the existing under-performed operations. Mixing in the reactor requires enormous amount of energy to achieve required homogeneity. Reduction in the energy consumption and ultimately the cost of the product is possible by devising smart mixing strategies. In this review, interactions of mixing and reaction kinetics of enzymatic hydrolysis, fermentation, and cellulosic depolymerization in ionic solvents are discussed. When the processes are operated under various mixing conditions, changes in the reaction kinetics and dynamics of the processes occur. Therefore, analyzing the mixing effects at various levels (micro to macro) is crucial to decide best operating mixing conditions that drive the reaction kinetics toward the increased product yield. The review is helpful to identify a suitable mixing strategy that maximizes the production of biofuelsethanol, 5-hydroxymethylfurfural, etc.