To meet the requirement of selective removing environmental carcinogen, elaborated microporous interspaces were successfully fabricated inside the channel of mesoporous silica SBA-15. The discarded cigarette filters (CF) and ferric nitrate solution were infused into SBA-15, and carbonized to form carbon and FexO particles tailoring the tortuosity of mecsoporous channels and provide the necessary electrostatic interaction towards tobacco specific nitrosamines (TSNA) in solution. Besides, the carefully modified SBA-15 displayed evidently selectivity towards 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK) and the representative sample Fe0.9CF1.2/S15c owned excellent performances in various tobacco solutions, with the high NNK-selectivity up to 58%, same as that of HZSM-5 zeolite. This strategy created new sorbents combining the high capability of mesoporous silica and the selectivity of microporous zeolite, giving certain enlightenment for new functional materials and environmental protection.