Water scarcity at global level has called for attentions to establish new and innovative technologies that can be tapped to provide sustainable solutions to water crisis. Membrane-based desalination has been acknowledged as one of the promising approaches to resolve the global challenges. Currently, different membrane-based technologies have been deployed worldwide for clean water production. However, despite the great advances made in terms of the permeate flux and rejection, the practical application of membrane for desalination is still limited by the inevitable membrane fouling issue. Membrane fouling is known to be the major culprit to the elevated operating costs due to the deterioration of permeate flux, increasing transmembrane pressure, and frequent chemical cleaning which shorten the membrane's lifespan. This review provides insights into the recent advancement in mitigating membrane desalination fouling. The fouling control strategies which encompass the efforts made in the novel membrane development, feed water pretreatment, and membrane cleaning are highlighted. The advantages and limitations of these techniques are discussed and reviewed based on a substantial number of up-to-date literatures.