Experimental vapor liquid equilibrium data are reported for the binary systems of perfluorooctane + either oxygen, nitrogen, or methane. Isothermal measurements were performed within the temperature range of 293.21 to 353.23 K, and at pressures up to 21 MPa, using two apparatuses; one based on the "static-analytic" method and the other on the "static synthetic" method. The experimental data were correlated using the perturbed-chain statistical associating fluid theory equation of state. The model provides a satisfactory representation of the experimental data within the measured temperature range.