The solid-liquid equilibrium for thiamphenicol in 13 neat solvents (ethanol, methanol, n-propanol, isopropyl alcohol, n-butanol, acetone, acetonitrile, ethyl acetate, 2-butanone, toluene, water, N,N-dimethylformamide, and 1,4-dioxane) was built with the static method at temperatures T = (278.15 to 318.15) K under pressure of 101.2 kPa, and the thiamphenicol solubilities in the selected solvents were measured by using high-performance liquid chromatography. Generally, the solubility data in mole fraction in the selected solvents ranked as N,N-dimethylformamide > acetone > methanol >1,4-dioxane >2-butanone > ethanol > acetonitrile > ethyl acetate > n-propanol > isopropyl alcohol > water > n-butanol > toluene. The nonrandom two-liquid model, Wilson model, modified Apelblat equation, and lambda h equation were employed to describe the solubility behavior of thiamphenicol in theses solvents. The maximum values of the RMSD and RAD were 4.08 X 10(-4) and 2.02%, respectively, and the correlation results by using the modified Apelblat equation were best among the studied models. Additionally, the mixing properties, activity coefficient at infinitesimal concentration and reduced excess enthalpy were derived.