ICR studies of the interactions between methanol and the family of MoxOy ions (x = 1-3, y = 1-9) in the gas phase are reported. Molybdenum oxide ions participate in four types of reactions with the CH3OH molecule that show rather profound similarities with the reactions of methanol over heterogeneous and homogeneous catalysts containing molybdenum-oxygen sites. Molybdenum oxide ions with three metal atoms represent coupling Of two and three hydrocarbon fragments of CH3OH to form longer hydrocarbon chains. The formation of acidic proton of MoxOyH+ (x = 1-3, y = 2-9) was found in interactions with CH3OH2+ and its solvates CH3OH2+.(CH3OH)(n) with n = 1, 2. Acidic protons are able to provide coupling of hydrocarbon fragments of alcohol molecules to produce finally alkenes and alkanes.