Closures such as buttons, clasps, zippers, and hook-and-loops find widespread use in daily life, and all work by mechanical interlocking. However, these traditional closures are often rigid, lose performance with age, and can produce a harsh sound during use. Here high strength (> 50 N cm(-2)), reusable, and nearly silent closure devices are fabricated based on recently developed fibril-less gecko-inspired adhesives. Guided by a reversible adhesion scaling law, the closure force capacity is tuned by modifying the closure materials and geometry. A simple analytical model is presented which accurately predicts system performance, based on the reversible adhesion scaling parameter. The force capacity of these adhesive closures is measured and compared to commercially-available hook-and-loop closures, and it is found that the adhesive closures sustain forces that are 4.4 times greater for comparable geometry. The sound of release is also quantified and shown to be minimal for adhesive closures. This work provides motivation to develop new high strength, reusable closures for commercial and industrial applications. (C) 2017 Wiley Periodicals, Inc.