Nanoconfined water flow plays a critical role in numerous engineering and industrial applications such as nanomedicine, nanofluidics, tribology, water purification, and energy storage and conversion, which has received tremendous research interest. A practical model has been developed that correlates the surface wettability, nanopore dimensions and confined water flow , though the essential physics still remains incompletely understood . The behaviors and flow of nanoconfined water and boundary conditions are fundamentally determined by the intermolecular interactions between water and the nanopore walls. The potential interdisciplinary significance and directions of this research field are discussed. (C) 2017 Elsevier Ltd. All rights reserved.