The outstanding degrading abilities of Phanerochaete chrysosporium is solely dependent on its lignocellulolytic, aromatic compound degrading and detoxifying enzymes. However, the gene expression and protein turnover of lignocellulolytic enzymes are controlled at cellular level by various genes involved in information storage and processing KOG group. Understanding the gene expression patterns and mechanisms involved in regulation of lignocellulose degrading enzymes will significantly help in strain improvement and developing recombinant strains. To study the common expression patterns, we have retrieved P. chrysosporium gene expression datasets from NCBI GEO and analyzed using GeneSpring (R). software based on the genome wide KOG annotations retrieved from JGI-MycoCosm database. Statistically significant genes obtained from our analysis were separated into replication, repair and recombination, chromatin structure and dynamics, transcription factors, RNA processing and modification and translation, ribosomal structure and biogenesis processes. We have observed various genes encoding for DNA damage, repair and recombination, mRNA splicing, amidases, polyadenylate binding factors, heat shock, helix loop helix, HMG-box, CCAAT (HAP5), CRE-B transcription factors, histone acetyl transferases (MYST, SAGA) commonly expressed among the datasets of natural plant biomass growth substrates. Further studies must be conducted to understand the role and involvement of these significant genes in plant biomass degradation by P. cluysosporium.