Wastewater treatment plant (WWTP) effluent is one of the most bulk water body that carries organic matters which is promising for energy catching, but it also contains complex un-degradable organic matters with low concentrations. Integration of advanced treatment of Wastewater treatment plant (WWTP) effluent and electricity generation is an attractive method but rarely reported. We innovatively applied a photocatalytic fuel cell (PFC) with a highly efficient Er-Al co-doped ZnO photo-anode to treat the WWTP effluent, which realized simultaneous advanced organic matters removal, bacteria disinfection, and considerable electricity generation. In the constructed visible light-driven PFC system, the chemical oxygen demand (COD) and dissolved organic carbon (DOC) removal efficiencies achieved 69.7% and 53.0%, respectively. The soluble microbial products decreased significantly. Both of the total bacteria cell and Escherichia coil (E. coli) cell accounts showed a 99% disinfection efficiency. Advanced electricity generation capability was simultaneously observed, in which the open-circuit voltage, short-current density, and maximum power density were 0.55 V, 9.13 mu A cm(-2) and 1.83 W cm(-2), respectively, with the fill factor as high as 0.36. In summary, the proposed PFC open up more opportunities for WWTP effluent reusing and clean energy generation.