The Q-cascade is a type of model cascade that is particularly useful for studying multicomponent isotope separation. The cascade segmentation technique is further developed to optimize Q-cascades, which minimizes the relative total flow by splitting a cascade into smaller segments that each use the mass number of the virtual component as a decision variable. Application of this technique to Cadmium isotope separation shows that it is always effective. If the number of segments into which a cascade is split increases, then the minimum relative total flow decreases. A progressive segmentation strategy is developed to maximize the number of segments.