Parameter optimization of a multi-objective cascade in the multi-component mixture like maximizing of separation work relative to the number of centrifuges has too economical advantages in the centrifuge-based separation. In this paper, a cascade simulator program (CASIM) is developed to design an optimum cascade. Through CASIM, a realistic function for separation factors, (i), in relation to , cut, and feed flow rate is achieved. A real coded particle swarm optimization (RCPSO) program is implemented and developed in the CASIM to design an optimum cascade. It has been shown that the application of RCPSO to this problem guarantees finding the optimum solution. It is found that all the objective functions are achieved.