화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.59, 184-191, March, 2018
DOI10.1016/j.jiec.2017.10.022  Export Citation
Functionalized inclined-GaN based nanoneedles
Kwon-Ho Kim, Kyuseung Lee1, Hyeonaug Hong2, Dasom Yang2, WonHyoung Ryu2, †, Okhyun Nam1, †, and Yeu-Chun Kim†
  • Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea
  • 1Convergence Center for Advanced Nano Semiconductor (CANS), Department of Nano-Optical Engineering, Korea Polytechnic University (KPU), Siheung 15073, Republic of Korea
  • 2School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea
E-mail:, ,
Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods, one-dimensional nanoneedles are one of the promising methods for insertion with minimal invasiveness to a cell. Most of the previous studies have been conducted using vertical nanoneedle. Here, we synthesized new inclined nanoneedles and demonstrated a novel platform using inclined-gallium nitride nanoneedles (iGaN NNs) to facilitate efficient intracellular delivery. In our system, foreign molecules were successfully delivered into cytoplasm of a cell through the penetration of the cell membrane by the iGaN NNs.
Keywords:Inclined-GaN;Nanoneedle;Surface functionalization;Cell insertion;Intracellular delivery
  1. Deng C, Jiang YJ, Cheng R, Meng FH, Zhong ZY, Nano Today, 7(5), 467 (2012)
  2. Lee N, Yoo D, Ling D, Cho MH, Hyeon T, Cheon J, Chem. Rev., 115(19), 10637 (2015)
  3. Allen TM, Cullis PR, Adv. Drug Deliv. Rev., 65, 36 (2013)
  4. Probst CE, Zrazhevskiy P, Bagalkot V, Gao X, Adv. Drug Deliv. Rev., 65, 703 (2013)
  5. Yuan H, Fales AM, Vo-Dinh T, J. Am. Chem. Soc., 134(28), 11358 (2012)
  6. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP, Nat. Nanotechnol., 4(12), 876 (2009)
  7. Wu Y, Cai J, Han J, Baigude H, ACS Appl. Mater. Interfaces, 7, 21521 (2015)
  8. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L, Nat. Biotechnol., 23, 1418 (2005)
  9. Kim KN, Chun J, Kim JW, Lee KY, Park JU, Kim SW, Wang ZL, Baik JM, ACS Nano, 9, 6394 (2015)
  10. Huang CW, Chen JY, Chiu CH, Wu WW, Nano Lett., 14, 2759 (2014)
  11. Lee J, Lee P, Lee HB, Hong S, Lee I, Yeo J, Lee SS, Kim TS, Lee D, Ko SH, Adv. Funct. Mater., 23, 4171 (2013)
  12. Gong S, Schwalb W, Wang Y, Chen Y, Tang Y, Si J, Shirinzadeh B, Cheng W, Nat. Commun., 5 (2014)
  13. Peng F, Su Y, Ji X, Zhong Y, Wei X, He Y, Biomaterials, 35, 5188 (2014)
  14. Peng F, Su Y, Wei X, Lu Y, Zhou Y, Zhong Y, Lee ST, He Y, Angew. Chem.-Int. Edit., 52, 1457 (2013)
  15. Lee JH, Zhang A, You SS, Lieber CM, Nano Lett., 16, 1509 (2016)
  16. Robinson JT, Jorgolli M, Shalek AK, Yoon MH, Gertner RS, Park H, Nat. Nanotechnol., 7(3), 180 (2012)
  17. Wang Z, Yang Y, Xu Z, Wang Y, Zhang W, Shi P, Nano Lett., 15, 7058 (2015)
  18. Yum K, Yu MF, Wang N, Xiang YK, Biochim. Biophys. Acta, 1810, 330 (2011)
  19. Zhu X, Yuen MF, Yan L. Zhang Z, Ai F, Yang Y, Yu PK, Zhu G, Zhang W, Chen X, Adv. Healthc. Mater., 5, 1157 (2016)
  20. Obataya I, Nakamura C, Han S, Nakamura N, Miyake J, Biosens. Bioelectron., 20, 1652 (2005)
  21. Chan MS, Lo PK, Small, 10, 1255 (2014)
  22. Yoo SM, Kang M, Kang T, Kim DM, Lee SY, Kim B, Nano Lett., 13, 2431 (2013)
  23. Park S, Kim YS, Kim WB, Jon S, Nano Lett., 9, 1325 (2009)
  24. Han SW, Nakamura C, Obataya I, Nakamura N, Miyake J, Biochem. Biophys. Res. Commun., 332(3), 633 (2005)
  25. Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y, ACS Nano, 8, 3821 (2014)
  26. Yum K, Na S, Xiang Y, Wang N, Yu MF, Nano Lett., 9, 2193 (2009)
  27. Matsumoto D, Sathuluri RR, Kato Y, Silberberg YR, Kawamura R, Iwata F, Kobayashi T, Nakamura C, Sci. Rep., 5, 15325 (2015)
  28. Chiappini C, Martinez JO, De Rosa E, Almeida CS, Tasciotti E, Stevens MM, ACS Nano, 9, 5500 (2015)
  29. Chiappini C, De Rosa E, Martinez JO, Liu X, Steele J, Stevens MM, Tasciotti E, Nat. Mater., 14(5), 532 (2015)
  30. Chiappini C, Campagnolo P, Almeida CS, Abbassi-Ghadi N, Chow LW, Hanna GB, Stevens MM, Adv. Mater., 27(35), 5147 (2015)
  31. Wang Y, Yang Y, Yan L, Kwok SY, Li W, Wang Z, Zhu X, Zhu G, Zhang W, Chen X, Nat. Commun., 5 (2014)
  32. Foster CM, Collazo R, Sitar Z, Ivanisevic A, Langmuir, 29(26), 8377 (2013)
  33. Chen CR, Young TH, Biomaterials, 29, 1573 (2008)
  34. Jewett SA, Makowski MS, Andrews B, Manfra MJ, Ivanisevic A, Acta Biomater., 8, 728 (2012)
  35. Yang D, Hong H, Seo YH, Kim LH, Ryu W, ACS Appl. Mater. Interfaces, 7, 16873 (2015)
  36. Lee K, Chae S, Jang J, Min D, Kim J, Eom D, Yoo YS, Cho YH, Nam O, Nanotechnology, 26, 335601 (2015)
  37. Lee K, Chae S, Jang J, Min D, Kim J, Nam O, AIP Adv., 6, 045209 (2016)
  38. Chae S, Lee K, Jang J, Min D, Kim J, Nam O, J. Cryst. Growth, 409, 65 (2015)
  39. Kam NWS, Liu Z, Dai HJ, J. Am. Chem. Soc., 127(36), 12492 (2005)
  40. Seo YH, Kim LH, Kim YB, Ryu W, Nanoscale, 5, 7809 (2013)
  41. Kim LH, Kim YJ, Hong H, Yang D, Han M, Yoo G, Song HW, Chae Y, Pyun JC, Grossman AR, Ryu W, Adv. Funct. Mater., 26(42), 7679 (2016)
  42. Rostgaard KR, Frederiksen RS, Liu YCC, Berthing T, Madsen MH, Holm J, Nygard J, Martinez KL, Nanoscale, 5, 10226 (2013)