pH Sensitive Soft Contact Lens for Selective Drug-Delivery

Guenhei Kim; Hyeok Jung Kim; Hyeran Noh

Macromolecular Research, Vol.26, No.3, 278-283, March, 2018

DOI10.1007/s13233-018-6029-9 Export Citation

pH Sensitive Soft Contact Lens for Selective Drug-Delivery

Guenhei Kim¹, Hyeok Jung Kim², and Hyeran Noh^{1, 2, †}

¹Convergence Institute of Biomedical Eng. & Biomaterial, Seoul National University of Science and Technology, Seoul 01811, Korea
²Department of Optometry, Seoul National University of Science and Technology, Seoul 01811, Korea

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In this study, we evaluated contact lenses as drug delivery media and the effect of tear physiological pH on drug release behavior. Anionic or cationic hydroxyethyl methacrylate (HEMA) lenses were polymerized with either vinylpyrrolidone (VP) or N-isopropylacrylamide (NIPAAm). The pH of artificial tears was prepared as between 5.8 and 8.35. One of common treatments, hydroxypropyl methylcellulose (HPMC), to dry eye disease was used as a test drug. As a result, drug releases from anionic 100% p-HEMA and p-HEMA-VP lens were both increased with increasing tear pH. However, released drug amounts from cationic the p-HEMA-NIPAAm lens were decreased with increasing pH. In weak basicity (pH 8.03), the p-HEMA-VP (20 wt%) lens swelled resulting releasing drugs 3.5 times more compared to in weak acidity (pH 5.80). On the other hand, the p-HEMA-NIPAAm (20 wt%) lens de-swelled in basic solution resulting decreased drug release compared to in acidic solution. The hydrogel contact lenses showed various physical properties and drug releasing properties including diffusion coefficients in response to ionization reactions between ionic groups in the lens and pH of solution. It suggests that hydrogel contact lens has potential as selective drug delivery media.

Keywords:hydrogel;contact lens;dry eye;drug delivery;ionic polymer

[References]

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Singh E, Katheria AD, Srivastava R, Kumar U, Yadav BC, Imperial J. Int. Res., 6, 336 (2016)
Maulvi FA, Lakdawala DH, Shaikh AA, Desai AR, Choksi HH, Vaidya RJ, Ranch KM, Koli AR, Vyas BA, Shah DO, J. Control. Release, 226, 47 (2016)
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Alvarez-Lorenzo C, Hiratani H, Concheiro A, Am. J. Drug Deliv., 4, 131 (2006)
White CJ, McBride MK, Pate KM, Tieppo A, Byrne ME, Biomaterials, 32, 5698 (2011)
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Kim J, Conway A, Chauhan A, Biomaterials, 29, 2259 (2008)
Gambhire SAVITA, Bhalerao KARUNA, Singh SUSHMA, Int. J. Pharm. Pharm. Sci., 5, 27 (2013)
Verestiuc L, Nastasescu O, Barbu E, Sarvaiya I, Green KL, Tsibouklis J, J. Biomed. Mater. Res. Part A, 77, 726 (2006)
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Jung HJ, Chauhan A, Biomaterials, 33, 2289 (2012)
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Yamada M, Mochizuki H, Kawai M, Yoshino M, Mashima Y, Current Eye Res., 16, 482 (1997)
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Rhim, WI, Lee HS, Yun YS, Choi HJ, J. Korean Ophthalmol. Soc., 44, 931 (2003)
Alvarez-Lorenzo C, Hiratani H, Gomez-Amoza JL, Martinez-Pacheco R, Souto C, Concheiro A, J. Pharm. Sci., 91, 2182 (2002)
Mahomed A, Wolffsohn JS, Tighe BJ, Contact Lens Anterior Eye, 39, 97 (2016)
Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)
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Cai K, Huang Y, Yang JL, J. Am. Ceram. Soc., 88(12), 3332 (2005)
Ray D, Sahoo PK, Mohanta GP, Asian J. Pharm., 4, 123 (2008)
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Wei H, Cheng SX, Zhang XZ, Zhuo RX, Prog. Polym. Sci, 34, 893 (2009)
Bearat HH, Lee BH, Valdez J, Vernon BL, J. Biomater. Sci., 22, 1299 (2011)
Kim B, Peppas NA, Biomed. Microdevices, 5, 333 (2003)
Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)
Martin-Montanez V, Lopez-Miguel A, Arroyo C, Mateo ME, Gonzalez-Meijome JM, Calonge M, Gonzalez-Garcia MJ, J. Biomed. Mater. Res. Part B: Appl. Biomater., 102, 764 (2014)
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[Referenced By]

[1] White CJ, Tieppo A, Byrne ME, J. Drug Deliv. Sci. Technol., 21, 369 (2011)

[2] Singh E, Katheria AD, Srivastava R, Kumar U, Yadav BC, Imperial J. Int. Res., 6, 336 (2016)

[3] Maulvi FA, Lakdawala DH, Shaikh AA, Desai AR, Choksi HH, Vaidya RJ, Ranch KM, Koli AR, Vyas BA, Shah DO, J. Control. Release, 226, 47 (2016)

[4] Holly FJ, Optom. Vis. Sci., 58, 331 (1981)

[5] Alvarez-Lorenzo C, Hiratani H, Concheiro A, Am. J. Drug Deliv., 4, 131 (2006)

[6] White CJ, McBride MK, Pate KM, Tieppo A, Byrne ME, Biomaterials, 32, 5698 (2011)

[7] Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS, Invest. Ophthalmol. Vis. Sci., 50, 3346 (2009)

[8] Fernando Y, Angel C, Carmen AL, Eur. J. Pharm. Biopharm., 69, 1094 (2008)

[9] Kim J, Conway A, Chauhan A, Biomaterials, 29, 2259 (2008)

[10] Gambhire SAVITA, Bhalerao KARUNA, Singh SUSHMA, Int. J. Pharm. Pharm. Sci., 5, 27 (2013)

[11] Verestiuc L, Nastasescu O, Barbu E, Sarvaiya I, Green KL, Tsibouklis J, J. Biomed. Mater. Res. Part A, 77, 726 (2006)

[12] Maulvi FA, Soni TG, Shah DO, J. Biomater. Sci., Polym. Ed., 26, 1035 (2015)

[13] Tieppo A, White CJ, Paine AC, Voyles ML, McBride MK, Byrne ME, J. Control. Release, 157, 391 (2012)

[14] Qiu Y, Park K, Adv. Drug Deliv. Rev., 53, 321 (2001)

[15] Jung HJ, Chauhan A, Biomaterials, 33, 2289 (2012)

[16] Paradiso P, Galante R, Santos L, de Matos APA, Colaco R, Serro AP, Saramago B, J. Biomed. Mater. Res. Part B: Appl. Biomater., 102, 1170 (2014)

[17] Abelson MB, Udell IJ, Weston JH, Arch. Ophthalmol., 99, 301 (1981)

[18] Yamada M, Mochizuki H, Kawai M, Yoshino M, Mashima Y, Current Eye Res., 16, 482 (1997)

[19] Norn MS, Acta Ophthalmol., 66, 485 (1988)

[20] Thygesen JEM, Jensen OL, Acta Ophthalmol., 65, 134 (1987)

[21] Rhim, WI, Lee HS, Yun YS, Choi HJ, J. Korean Ophthalmol. Soc., 44, 931 (2003)

[22] Alvarez-Lorenzo C, Hiratani H, Gomez-Amoza JL, Martinez-Pacheco R, Souto C, Concheiro A, J. Pharm. Sci., 91, 2182 (2002)

[23] Mahomed A, Wolffsohn JS, Tighe BJ, Contact Lens Anterior Eye, 39, 97 (2016)

[24] Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)

[25] Korsmeyer RW, Peppas NA, J. Membr. Sci., 9, 211 (1981)

[26] Cai K, Huang Y, Yang JL, J. Am. Ceram. Soc., 88(12), 3332 (2005)

[27] Ray D, Sahoo PK, Mohanta GP, Asian J. Pharm., 4, 123 (2008)

[28] Zhang R, Tang M, Bowyer A, Eisenthal R, Hubble J, Biomaterials, 26, 4677 (2005)

[29] Wei H, Cheng SX, Zhang XZ, Zhuo RX, Prog. Polym. Sci, 34, 893 (2009)

[30] Bearat HH, Lee BH, Valdez J, Vernon BL, J. Biomater. Sci., 22, 1299 (2011)

[31] Kim B, Peppas NA, Biomed. Microdevices, 5, 333 (2003)

[32] Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)

[33] Martin-Montanez V, Lopez-Miguel A, Arroyo C, Mateo ME, Gonzalez-Meijome JM, Calonge M, Gonzalez-Garcia MJ, J. Biomed. Mater. Res. Part B: Appl. Biomater., 102, 764 (2014)

[34] Noh H, Polym. Korea, 36(2), 190 (2012)