화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.61, 244-254, May, 2018
DOI10.1016/j.jiec.2017.12.022  Export Citation
Preparation and characterization of spiral-like micro-struts with nano-roughened surface for enhancing the proliferation and differentiation of preosteoblasts
Gi-Hoon Yang, Hyeongjin Lee1, and GeunHyung Kim†
  • Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea
  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine,, Medical Center Boulevard, Winston-Salem, NC, USA
E-mail:
Factors that are important for the development of tissue-engineered scaffolds include an appropriate selection of the physiochemical structure and surface characteristics to achieve the desired cellular responses depending on the target tissue or organ. In this study, we designed the linear polycaprolactone (PCL) strut, a spiral-like PCL strut that was fabricated using a 3D melt-printing system and a modified spiral-like PCL strut via a 3D melt-printing/plasma-etching process. The surface-roughened spiral-like strut showed significantly enhanced wettability and protein absorption abilities, which were closely related to cellular activities compared to those of linear and spiral-like struts. The in vitro cellular activities using the preosteoblasts (MC3T3-E1) indicated that the newly designed surface-modified spiral-like structure showed significantly higher metabolic activities and mineralization compared to those of conventionally 3D-printed struts.
Keywords:3D printing;Biomedical scaffold;Tissue engineering
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