The effects of ultrasound on the hydrodynamic and mass transfer behaviors of immiscible liquid-liquid two-phase flow was investigated in a domestic ultrasonic microreactor. Under ultrasonic irradiation, cavitation bubble was generated and underwent violent oscillation. Emulsification of immiscible phases was initiated by virtue of oscillating bubbles shuttling through the water/oil interface. The pressure drop was found to decrease with increasing ultrasound power, with a maximum decrement ratio of 12% obtained at power 30 W. The mass transfer behavior was characterized by extraction of Rhodamine B from water to 1-octanol. An enhancement factor of 1.3-2.2 on the overall mass-transfer coefficient was achieved under sonication. The mass transfer performance was comparable to passive microreactor at similar energy dissipation rate (61-184 W/kg). The extraction equilibrium was reached under a total flow velocity 0.01 m/s and input power 20 and 30 W, exhibiting its potential use in liquid-liquid extraction process. (c) 2017 American Institute of Chemical Engineers AIChE J, 64: 1412-1423, 2018