The design of intensified systems remains an Edisonian effort, whereby new intensification schemes are the product of creativity rather than the result of applying systematic procedures. Under this motivation, this article presents a novel and systematic approach for identifying targets for thermal process intensification, defined as combining two or more heat sources and sinks present in a process flowsheet, possibly along with a thermal utility stream, in a single intensified device where heat exchange takes place. The targeting problem is formulated as a mixed-integer linear program. An extensive case study illustrating its application is presented. (C) 2017 American Institute of Chemical Engineers