When powder Sr/La2O3 catalysts are deposited on the walls of cordierite monoliths, an important increase in both, methane conversion and C-2 yield, takes place. In this work, it is shown that this improved catalytic behavior is due to a combination of physical and chemical factors. This conclusion was drawn after performing a systematic study in which several structured formulations were catalytically evaluated and characterized using different techniques (EDX, XRD, BET, XPS, LRS), which helped us to rationalize the experimental observations. It is suggested that the honeycomb structure provides a more homogeneous gaseous flow as compared with the powder catalyst. This fact results in a better contact between reactant and catalyst surface, which in turn results in an increase of the overall reaction rate. Furthermore, it is demonstrated that the catalytic layer enrichment with Mg and Si, coming from the cordierite structure, greatly contributes to the improved catalytic behavior.