Modeling of brain tumor growth simulator can estimate life expectancy for individual patients, estimate future effect of brain damages toward human senses and attitude and help in evaluating the efficiency of applied treatments. Brain tumor growth can be calculated based on Spatio-Temporal mathematical models namely the isotropic reaction-diffusion model and the anisotropic reaction-diffusion model where the second model produces more realistic results. Tumor normally grows in White Matter (WM) five times faster than in Gray Matter (GM) which makes brain tissues modeled as inhomogeneous - anisotropic material to assign different parameters to each tissue. In this research a comparative study between several tumor growth models has been achieved to clarify the effect of different algorithms on modeling tumor grow. (C) 2018 Elsevier Inc. All rights reserved.