Solvents, particularly those having low volatility, are of great interest for the biocatalytic synthesis of utility chemicals and fuels. We show novel and universal solvent-like properties of a neat and water-less polymer surfactant-bovine serum albumin (BSA) conjugated material (WL-PSpBSA). This highly viscous, nonvolatile material behaves as a liquid above its solid-liquid transition temperature (similar to 25-27 degrees C) and can be used as a solvent for variety of completely dry solutes of different sizes and surface chemistries. We show using a combination of optical microscopy and steady -state and time-resolved fluorescence spectroscopy that dry and powdered dyes (hydrophobic Coumarin 153 (C153)), enzymes (alpha-chymotrypsin (alpha-Chy)), or even 1 mu m microparticles (diffusion coefficient ca. three orders slower than C153), can be solubilized and completely dispersed in the WL-PSpBSA solvent above 25 degrees C. While C153, irrespective of its mode of addition to WL-PSpBSA, binds similarly to BSA, alpha-Chy can be stabilized and activated to perform its hydrolysis function, even at 100 degrees C. This work therefore provides insights into the form of universal solvent characteristic property for this new class of nonaqueous, nonvolatile, biodegradable protein-polymer surfactant-based conjugated materials and suggests potential new avenues that can have a huge impact on biocatalysis, bionanotechnology, drug delivery, and other applications.