Catalysis Letters, Vol.148, No.5, 1315-1323, 2018
Copper(II) Nitrate Catalyzed Azide-Alkyne Cycloaddition Reaction: Study the Effect of Counter Ion, Role of Ligands and Catalyst Structure
For the first time, CuAAC reaction catalyzed by copper(II) nitrate and counter ion effect of various copper(II) salts are reported. Use of a novel copper complex 1, derived from the reaction of copper(II) nitrate with 5-acetyl-2-amino-6-methyl-4-(pyridin-3-yl)-4H-pyran-3-carbonitrile, facilitated the CuAAC reaction at room temperature with a catalyst loading as low as 1 mol% within a very short reaction time. [GRAPHICS] .
Keywords:Click reaction;Copper nitrate;5-Acetyl-2-amino-6-methyl-4-(pyridin-3-yl)-4H-pyran-3-carbonitrile;Copper(II) nitrate pyridine complex;Counter ion effect